Peter Griffin is a big, boisterous, lovable oaf who isn't afraid to say what's on his freakin' mind -- usually the wrong thing at exactly the wrong time. He lives in Quahog, Rhode Island with his wife, Lois, their three children -- Chris, Meg and Stewie -- and his well-spoken best friend, Brian, the family dog. Peter would do anything for his family, as long as it doesn't get in the way of his TV time.  He currently works as a fisherman.

Lois Griffin is a modern-day housewife who finds time to cook, clean, run errands, teach piano and avoid daily attempts on her life by her baby son, Stewie. Of course, a mother's love runs deep. So deep in this case, that Lois is blind to Stewie's matricidal intentions, attributing his perpetual foul mood to plain old crankiness.

Stewie Griffin is a 1-year-old baby with a single goal: Total world domination. He has the voice and manner of an evil Rex Harrison, but he's only recently celebrated the one-year anniversary of his escape from his mother's "cursed ovarian Bastille," in which he was incarcerated for nine gruelling months. Stewie has vowed to defeat his mother's matriarchal tyranny and topple the "gynocracy" she rules.

Chris Griffin is an overgrown, sweet-hearted 13-year-old who looks imposing, but wouldn't hurt a fly. (Unless it landed on his hot dog, his favorite food.) In that case, Chris would probably treat the fly as a condiment.

Sixteen-year-old Meg Griffin lives a difficult life. Just ask her. From having thin lips to being unpopular, Meg is constantly struggling to gain acceptance from the "in" crowd, or any crowd for that matter.